Biologic therapies for juvenile arthritis
نویسندگان
چکیده
منابع مشابه
Biologic therapies for juvenile arthritis.
A group of therapies with exciting potential has emerged for children and young people with severe juvenile idiopathic arthritis (JIA) uncontrolled by conventional disease modifying drugs. Theoretical understanding from molecular biologic research has identified specific targets within pathophysiological pathways that control rheumatoid arthritis (RA) and JIA. This review identifies the pathway...
متن کاملBARBARA ANSELL SERIES Biologic therapies for juvenile arthritis
A group of therapies with exciting potential has emerged for children and young people with severe juvenile idiopathic arthritis (JIA) uncontrolled by conventional disease modifying drugs. Theoretical understanding from molecular biologic research has identified specific targets within pathophysiological pathways that control rheumatoid arthritis (RA) and JIA. This review identifies the pathway...
متن کاملLong-term experience with biologic therapies for the treatment of polyarticular juvenile idiopathic arthritis
The introduction of biological therapies opened a new era for the treatment of polyarticular juvenile idiopathic arthritis. Remission of disease is now a goal well within reach for many patients. It is now more than a decade since the first biologics for treatment of pediatric rheumatic disease were approved. Long-term effects regarding safety and efficacy are of great interest and these data a...
متن کاملJuvenile idiopathic arthritis--current and future therapies.
Juvenile idiopathic arthritis (JIA) consists of a group of heterogeneous disorders of chronic arthritis in childhoodwith no apparent cause. JIA is the most common rheumatic disease in children and may still result in signifcant morbidity, with joint deformity, growth impairment, and persistence of active arthritis into adulthood. In addition to arthritis, the extra-articular features that may b...
متن کاملBiologic therapies and systemic bone loss in rheumatoid arthritis.
Chronic inflammation affects bone metabolism leading to disequilibrium in the rates of bone resorption and repair and subsequently to local and generalized bone loss. Osteoporosis represents an important co-morbidity of rheumatoid arthritis (RA) patients, which exhibit increased fracture risk. Osteoclasts play a pivotal role in the development and progression of bone loss, while resident synovi...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 2003
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.88.3.186